Allergen-specific IgE
Used in the evaluation of suspected IgE-mediated allergies, together with symptoms and clinical assessment.
A positive result can indicate sensitization. It does not independently confirm a clinical allergy.
Specific IgG4 test.
Measures specific IgG4 antibody responses across 42 panel entries. Uses the same service process as the IgE test, with a different interpretation. IgG4 is not a standalone diagnosis of food allergy or intolerance.
$99.00 USD base price · one-time testA different antibody measurement from IgE. Explore the 42-entry panel. Price & availability
Available for purchase. Clinical authorization and collection are separate steps. Any applicable fees are shown before payment.
IgG4 at a glance.
- Measurement
- Allergen-specific IgG4
- Panel scope
- 42 entriesCombined targets count once
- Specimen
- SerumSubject to the final approved workflow
- Base price
- $99.00 USDOne-time test
The reference includes combined targets. 42 entries does not mean 42 distinct clinical allergies.
What does an IgG4 measurement actually mean?
IgG4 measures a different antibody subclass from IgE. It is not a standalone diagnostic test for food allergy or intolerance, an upgraded allergy test, or a necessary add-on to this panel.
IgG4 is one subclass of IgG antibodies produced as part of immune responses to certain antigens. Specific IgG4 may be associated with exposure and changes in immune response. Its significance varies by context.
Allergen-specific IgG4
A different antibody response that may reflect exposure or immune-related processes.
It is not a standalone diagnostic marker for food allergy or intolerance.
IgG4 is not an upgraded version of IgE testing or a necessary add-on to an IgE panel. A measurable response does not identify an allergy or food intolerance by itself. Diagnostic and treatment decisions require appropriate clinical evaluation.
Explore all 42 targets.
Browse the reference panel, from environmental sources to food-related proteins. Search by common or scientific name.
All targets
01House dust miteD. pteronyssinus
A species of house dust mite commonly included in allergy-related laboratory panels.
Scientific name: Dermatophagoides pteronyssinus
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
02House dust miteD. farinae
A second species of house dust mite, listed as its own panel entry.
Scientific name: Dermatophagoides farinae
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
03Cat epithelium & danderCat epithelium & dander
Cat-derived epithelium and dander are listed together as one entry; they are not counted as separate results.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
04Dog danderDog dander
A dog-dander target in the reference panel.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
05Alder & birchAlder/BirchCombined entry
Alder and birch are listed together as one combined entry. This listing does not provide separate results for each tree.
Listed together: Alder · Birch. One panel entry.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
06OakOak
An oak-related pollen entry in the reference panel.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
07Four-grass mixtureSweet vernal grass / Bermuda grass / Orchard grass / Timothy grassCombined entry
Sweet vernal, Bermuda, orchard, and Timothy grasses form one combined entry. The four grass names do not represent four separate panel results.
Listed together: Sweet vernal grass · Bermuda grass · Orchard grass · Timothy grass. One panel entry.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
08Common ragweedCommon ragweed
A common-ragweed pollen target in the reference panel.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
09MugwortMugwort
A mugwort-related pollen target in the reference panel.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
10Japanese hopJapanese hop
A Japanese-hop pollen target in the reference panel.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
11Aspergillus fumigatusAspergillus fumigatus
A target associated with the mold Aspergillus fumigatus.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
12Penicillium notatumPenicillium notatum
A target associated with the mold named Penicillium notatum in the source reference.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
13Alternaria alternataAlternaria alternata
A target associated with the mold Alternaria alternata.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
14Bee venomBee venom
A bee-venom target. A specific IgG4 measurement does not establish venom allergy or reaction severity.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
15Wasp venomWasp venom
A wasp-venom target. A specific IgG4 measurement does not establish venom allergy or reaction severity.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
16CockroachCockroach
A cockroach-related target in the reference panel.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
17PorkPork
A pork-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
18BeefBeef
A beef-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
19ChickenChicken
A chicken-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
20Egg yolkEgg yolk
The yolk portion of an egg is listed separately from egg white.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
21Egg whiteEgg white
The white portion of an egg is listed separately from egg yolk.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
22MilkMilk
Milk is listed as an entry alongside several separately named milk proteins.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
23CaseinCasein
A milk protein, listed as a separate target in this panel.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
24Alpha-lactalbuminα-lactalbumin
A milk protein, listed separately under the source label α-lactalbumin.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
25Beta-lactoglobulinβ-lactoglobulin
A milk protein, listed separately under the source label β-lactoglobulin.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
26CodCodfish
A cod-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
27MackerelMackerel
A mackerel-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
28CrabCrab
A crab-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
29ShrimpShrimp
A shrimp-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
30Blue mussel & oysterBlue mussel/OysterCombined entry
Blue mussel and oyster are listed together as one combined entry, not two separate panel results.
Listed together: Blue mussel · Oyster. One panel entry.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
31WheatWheat
A wheat-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
32BuckwheatBuckwheat
A buckwheat-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
33RiceRice
A rice-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
34SoybeanSoy bean
A soybean-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
35PeanutPeanut
A peanut-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
36WalnutWalnut
A walnut-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
37AlmondAlmond
An almond-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
38PeachPeach
A peach-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
39AppleApple
An apple-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
40KiwiKiwi
A kiwi-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
41MangoMango
A mango-related food target in the reference panel. Its presence does not indicate whether the food can be safely consumed.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
42Alpha-galα-Gal (Thyroglobulin)
One alpha-gal entry, with thyroglobulin named in the source label. Thyroglobulin is not an additional target. This specific IgG4 measurement is different from alpha-gal-specific IgE testing used in evaluating alpha-gal syndrome.
An IgG4 response to this target does not, on its own, establish an allergy, food intolerance, or reaction severity.
manufacturer panel reference — verification pending
The final menu must be reconciled with current manufacturer instructions and the laboratory’s validated configuration before clinical use.
Report overview.
IgG4 is a subclass of IgG antibodies. Select a target to explore this illustrative report’s structure and interpretation limits.
Illustrative report — not actual patient results.
Indoor & Animals · 5 entries
Choose an entry to explore what it represents.
House dust mite
Dermatophagoides pteronyssinus
- Allergen group
- Indoor & Animals
- Antibody measured
- Specific IgG4
- Panel structure
- One panel entry
What this entry represents
A species of house dust mite commonly included in allergy-related laboratory panels. Specific IgG4 is a different antibody measurement from IgE. It does not independently diagnose food allergy or intolerance.
House dust mite
Dermatophagoides pteronyssinus
- Allergen group
- Indoor & Animals
- Antibody measured
- Specific IgG4
- Panel structure
- One panel entry
What this entry represents
A species of house dust mite commonly included in allergy-related laboratory panels. Specific IgG4 is a different antibody measurement from IgE. It does not independently diagnose food allergy or intolerance.
What this measurement does not establish
- Specific IgG4 is not a standalone diagnosis of food allergy or intolerance.
- A clinical allergy or its severity
- Food intolerance or “hidden food sensitivity”
- Which foods you should avoid
- Whether an individual’s immunotherapy is effective
No laboratory values, units, cutoffs, or risk bands are shown in this demonstration.
What IgG4 does not establish.
- A clinical allergy or its severity
- Food intolerance or “hidden food sensitivity”
- Which foods you should avoid
- Whether an individual’s immunotherapy is effective
IgG4 measurements are not a standalone diagnosis of allergy or food intolerance. Findings must not be converted into food-avoidance recommendations.
Price, availability and practical details.
$99.00 USD per test. One-time testing, with no membership or automatic renewal.
Uses the same service process as the IgE test. Eligibility review and medical authorization are planned where required. Collection arrangements, locations, preparation and turnaround will be confirmed before ordering.
Serum, subject to the final approved workflow.
Collection, clinician, shipping and consultation fees have not been confirmed as included. Any additional fees will be explained before ordering.
Future clinical reports would use approved laboratory documentation and appropriate review.
Review IgG4 Sandbox checkoutIgG4 questions.
Clear explanations for a different antibody measurement.
Measurement & panel
What is IgG4?
IgG4 is one subclass of immunoglobulin G, an antibody produced by the immune system. Its presence can reflect immune responses and exposure; it does not, by itself, establish an allergy or disease.
What does an allergen-specific IgG4 test measure?
It measures IgG4 antibodies directed against defined target antigens. This panel describes specific responses to the listed targets, rather than the total concentration of all IgG4 in serum.
Is IgG4 the same as IgE?
No. They are different antibody types with different interpretations. Specific IgE contributes to evaluation of suspected IgE-mediated allergy alongside symptoms and clinical assessment. IgG4 cannot be interpreted in the same way.
Explore IgE allergy testingDoes the panel contain only food allergens?
No. The 42 reference entries include indoor and animal-related targets, pollens, molds, insect venoms, food-related targets, and an alpha-gal entry.
How many targets are measured?
The supplied reference panel lists 42 entries, including combined alder/birch, grass, and blue mussel/oyster entries. Each combined entry counts once. The alpha-gal entry also counts once; thyroglobulin is part of its source label, not an additional target. The final menu remains subject to manufacturer and laboratory verification.
Interpretation & use
Can IgG4 testing diagnose food allergies?
No. Professional allergy organizations recommend against using food-specific IgG or IgG4 testing to diagnose food allergy. A specific IgG4 finding does not establish a clinical allergy.
Read the professional guidanceCan it diagnose food intolerance or sensitivity?
No. Current professional guidance does not support food-specific IgG4 testing as a diagnostic test for food intolerance or sensitivity. Such measurements should not be used to explain nonspecific symptoms on their own.
Does a higher IgG4 result mean that an allergen is dangerous?
No. An antibody measurement alone does not demonstrate clinical danger or predict how severe an allergic reaction may be.
Can I use this test to decide which foods to avoid?
No. Dietary restrictions should not be based solely on a food-specific IgG4 result. Discuss suspected food reactions and any dietary changes with a qualified healthcare professional.
Is IgG4 used in immunotherapy research?
Yes. IgG4 responses and changes have been studied during allergen immunotherapy. However, IgG4 levels alone are not reliable indicators of an individual’s clinical treatment response, and routine testing for that purpose is not recommended in clinical practice.
Price & availability
When can I order the test?
Available for purchase. Specific IgG4 uses the same service process as the IgE test. Review eligibility, collection availability and the complete total during checkout. Configured Sandbox checkout is for test payments only.
What does the IgG4 test cost?
The current one-time base price is shown in Price & availability. Review the complete total, including any applicable fees and tax, before payment. The service covers specific IgG4 with 42 panel entries. There is no membership or automatic renewal.
Price and availabilityResearch context and references.
Where this measurement fits.
These are contexts in which specific IgG4 has been studied or may be considered. They are not approved indications for Claror’s future service.
Immune-response research
Specific IgG4 is investigated in studies of immune responses and allergen exposure.
Allergy immunotherapy research
Changes in IgG4 have been studied during allergen immunotherapy. Levels alone are not reliable indicators of treatment effectiveness for individual patients; routine measurement for this purpose is not recommended in clinical practice.
Selected specialist contexts
A specialist or researcher may consider IgG4 measurements alongside other information when a specific use is justified. A routine clinical use case for Claror has not been approved.
Not a validated standalone tool for
- Diagnosing food allergy
- Diagnosing food intolerance or hidden food sensitivity
- Selecting an elimination diet
- Predicting allergic reaction severity
- Establishing the efficacy of allergy immunotherapy
Why does this panel include foods?
The reference panel includes antigens from food and environmental sources because it measures antibody responses to a defined collection of targets.
Food-specific IgG4 can be associated with tolerance. A food’s presence on the menu does not mean the assay can determine whether it is safe for a person to eat. IgG4 findings must not be converted into food-avoidance recommendations.
Read the references.
The supplied panel corresponds to the PROTIA Specific IgG4 multiplex assay. A published platform comparison evaluates analytical measurement, not whether this product can diagnose disease, establish treatment effectiveness, or improve clinical outcomes.
- AAAAI: IgG food panel testing
Professional guidance on food-specific IgG testing and its limitations.
- EAACI task force report on food-specific IgG4
Why food-specific IgG4 is not recommended for diagnosing food allergy or intolerance.
- Clinical Practice Guideline: Immunotherapy for Inhalant Allergy
Guidance on evaluating treatment response, including the limits of IgG4 monitoring.
- Validation of a Multiplex Assay for Measuring Specific IgG4
An analytical comparison of PROTIA Specific IgG4 with another measurement platform; not proof of clinical benefit or US service approval.